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2024

BugSeq Bioinformatics Inc. Collaborative Effort to Develop and Validate an end-to-end Agnostic Diagnostic Assay Published

Introduction

BugSeq partnered with University of British Columbia Researchers, along with clinical and public health collaborators at Vancouver Coastal Health, BC Centre for Disease Control, and Canada’s Michael Smith Genome Sciences Centre to develop, automate, and validate an end-to-end metagenomic sequencing assay for agnostic detection of respiratory viral pathogens within 12-hours. The work was funded by the Biomedical Advanced Research and Development Authority (BARDA), part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services under contract number 75A50122C00027.

The results of this collaborative project were published last week in The Journal of Infectious Diseases. Gauthier et al. outlined the development and validation of a metagenomic sequencing assay, termed Rapid Pathogen Identification through Metagenomic Next-Generation Sequencing (RAPID-mNGS).

BugSeq Case Study: Providence Health Care

Introduction

Next generation sequencing (NGS) is transforming clinical microbiology. It has enabled an unprecedented understanding of microbes, from taxonomic identification to prediction of antimicrobial resistance and transmission. BugSeq’s turnkey bioinformatics platform enables the automated analysis of NGS for clinical and public health laboratories.

Providence Health Care In our inaugural case study, we had the opportunity to connect with the Medical Microbiologists and Molecular Scientists at St. Paul’s Hospital, Providence Health Care to understand what is involved in building a sequencing program. Providence Health Care provides patient and family centered health care to all British Columbians. St. Paul’s Hospital is a major academic tertiary-care hospital with over 700 inpatient beds, and provides care to some of Vancouver’s most vulnerable populations.